DEVELOPMENT AND CHARACTERIZATION OF TRANDOLAPRIL IMMEDIATE RELEASE TABLETS USING DIFFERENT SUPERDISINTEGRATING AGENTS

A potent non-sulfhydryl prodrug, trandolapril is transformed into the active substance, trandolaprilat, in liver. For obese individuals with mild-to-moderate essential hypertension, Trandolapril effective and safe. The elimination t1/2 of trandolaprilat are approximately 6 hours 16–24 hours, respectively. goal present work to develop immediate release tablet using various superdisintegrants. Crospovidone, Sodium starch glycolate Croscarmellose sodium concentrations 2%, 4%, 6% were used as superdisintegrating agents for optimization. Direct compression technique was make nine formulations (IRTR 1 IRTR 9). powder blends all batches evaluated different parameters know flow characteristics it found that blend had excellent compressibility characteristics. Then, compressed tablets tested quality control per IP. In formulation IRTR1-IRTR9, disintegration time observed 30.23 71.67 Sec more than 70% drug released 30 min. Thus, based on evaluation results, concluded (IR) successfully developed. Minimum seconds 90.56% min obtained IRTR3. KEYWORDS: Trandolapril, Immediate release, glycolate, crocarmellose